Amanda Cassatt: Pioneer Bridging Traditional Publishing and Web3 Innovation

Amanda Cassatt’s career trajectory tells the story of how technology visionaries evolve with markets. From her early days in digital publishing to her current role as a Web3 entrepreneur, Cassatt has consistently identified emerging opportunities where traditional industries meet blockchain innovation. Her background in science-oriented thinking—shaped by a Washington, D.C. upbringing where her mother studied neuroscience and her father worked in software development—equipped her to see connections others missed, ultimately positioning her at the forefront of Web3 brand strategy and NFT commerce development.

After graduating magna cum laude from Columbia University with a degree in English in 2013, Cassatt joined HuffPost as a special projects editor under founder Arianna Huffington. Rather than remaining in traditional media infrastructure, she recognized an opportunity to democratize content creation and launched Slant in March 2015. The platform introduced a radical shift in the creator economy: instead of platforms capturing the majority of advertising revenue, Slant ensured writers received the largest share of their content’s earnings—a model that prefigured many of today’s Web3 ownership principles.

Amanda Cassatt and the Ethereum Marketing Revolution

In 2016, Cassatt joined ConsenSys as Chief Marketing Officer, taking on the challenge of building Ethereum’s narrative at a critical growth phase. Recognizing that blockchain technology required more than technical documentation, she assembled a marketing team exceeding 50 professionals dedicated to supporting ConsenSys’s portfolio of over 50 companies, including infrastructure leaders like Infura and the breakthrough wallet platform MetaMask. Her work during this period wasn’t merely promotional—it involved crafting an entire ecosystem narrative that positioned Ethereum as the foundation for decentralized finance and Web3 applications. This period established Cassatt as an authority on translating complex blockchain concepts for mainstream adoption.

Founding Serotonin: The Web3 Agency That Transforms Brands

After departing ConsenSys in 2019, Cassatt founded Serotonin in 2020, establishing a marketing agency and product studio specifically designed to guide established brands through Web3 integration. As CEO, Cassatt leads the firm’s strategic direction, helping traditional enterprises understand and leverage blockchain technologies for competitive advantage. Her approach differs fundamentally from typical marketing consultancies—Serotonin combines strategy with product development, ensuring clients don’t just understand Web3 but can actually build sustainable business models within decentralized environments.

Mojito: Architecting the NFT Commerce Infrastructure

Alongside Serotonin, Cassatt co-founded and leads Mojito, an NFT trading and commerce platform that serves as the go-to infrastructure for brands seeking to launch NFT initiatives and digital commerce strategies. Rather than operating as a speculative trading venue, Mojito positions itself as the commercial layer for enterprise NFT adoption—allowing major corporations to manage collections, engage communities, and monetize digital assets with institutional-grade tools. This dual-company approach demonstrates Cassatt’s strategic thinking: Serotonin provides the strategy and advisory layer, while Mojito supplies the technical infrastructure and marketplace capabilities that transform strategy into executable commerce.

Web3 Marketing: From Practice to Education

In 2023, Cassatt published “Web3 Marketing: A Handbook for the Next Internet Revolution,” translating her decade of experience into accessible guidance for businesses navigating blockchain adoption. The handbook addresses a critical gap in the market—the shortage of practical, business-focused Web3 resources that bridge technical concepts with commercial applications. Rather than diving into cryptocurrency speculation or blockchain theory, Cassatt’s work focuses on how companies can leverage Web3 technologies for brand building, customer engagement, and new revenue streams.

Recognition and Legacy

Her contributions to Web3 innovation and digital entrepreneurship earned Cassatt recognition on both Forbes and Inc.'s prestigious “30 Under 30” lists in 2016, acknowledging her impact during an early stage of her career. Beyond professional accolades, Cassatt married Samuel Cassatt in 2019, establishing a personal foundation that grounds her continued work in Web3 entrepreneurship.

Amanda Cassatt’s evolution from traditional media innovator to Web3 infrastructure builder illustrates a broader pattern: the most successful Web3 entrepreneurs aren’t typically those born into cryptocurrency culture, but rather experienced professionals who recognized earlier that blockchain would transform how brands, commerce, and communities function. Her trajectory—from empowering individual writers, to scaling Ethereum’s ecosystem, to building Web3-native companies—demonstrates both strategic foresight and the ability to execute at scale. For industry observers tracking how traditional businesses integrate blockchain technology, Cassatt’s work with both Serotonin and Mojito provides a practical blueprint.