The third round of negotiations between the U.S. and Iran will involve sensitive topics such as uranium enrichment, with a complex and unpredictable process.

On April 26, under the mediation of Oman, the Iranian delegation held the third round of indirect negotiations with the US team on the Iranian nuclear issue and the lifting of US sanctions on Iran on April 26. According to media reports, one of the key issues in the expert-level negotiations will be whether the United States will allow Iran to continue uranium enrichment within the framework of its nuclear program, although Iran has repeatedly stressed that its nuclear program is only for peaceful civilian purposes. Witkov had said that Iran could limit uranium enrichment levels to 3.67 percent under the 2015 JCPOA, but he later reversed course and insisted that Iran should stop all uranium enrichment activities. In response, Iranian Foreign Minister Aragzi made it clear that Iran's uranium enrichment rights are "non-negotiable". However, Trump said on the 25th that he was willing to meet directly with Iran's Supreme Leader Ayatollah Ali Khamenei or President Pezeshizizyan, and said he was confident that an agreement could be reached. So as Iranian Foreign Minister Araghzi has described, he is currently "cautiously optimistic" about the negotiations, which means that although the negotiations are full of uncertainties, there is still hope for a deal.